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Discussion The present study demonstrated that stimulation with the Sirt1 agonists Res or SRT could suppress the microglial activation and apoptosis, reduce inflammation, trigger Gli-1 translocation from the cytoplasm to the nucleus and upregulate the protein expression levels of Shh, Ptc-1, Smo and Gli-1 following OGD/R in vitro

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This evaluation ought to account for age, sex, family history, prior medical history, environmental exposures, and other established risk determinants that may increase the likelihood of occult malignancy

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