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This defense mechanism is crucial in preventing premature aging and maintaining skin vitality

It achieves this by reducing skin lipid damage, decreasing the presence of inflammatory cells in the injured skin and peritoneal cavity, and specifically suppressing the performance of macrophages [171]

Indeed, the genome of zebrafish possesses orthologs of many mammalian genes known to be involved in bile salt homeostasis, including the FXR (named NR1H4 in fish) (Wen et al., 2021), and a 2022 study by Xiong and colleagues demonstrated that adding Citrobacter freundii GC01 isolated from grass carp intestine to the feed of mice and zebrafish resulted in altered bile acid profiles, while also affecting lipid metabolism and upregulating expression of a key gene (CYP7A1) in BA synthesis

Recent studies have shown that DAPA significantly lowers oxidative stress and inflammatory indicators (Abdel-Wahab et al