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Signs I don't want patients to ignore If any of these sound familiar, it's time to move beyond general advice and get evaluated: Loud persistent snoring especially if a bed partner notices pauses, choking, or gasping Morning headaches that happen often or feel tied to poor sleep Severe daytime sleepiness including dozing off unintentionally Waking with jaw pain or facial tension on a regular basis Dry mouth on waking which often points to mouth breathing Repeated awakenings with a sense of panic, air hunger, or a racing heart Tooth wear, clenching, or grinding that keeps progressing despite a night guard Restless, unrefreshing sleep even when time in bed seems adequate A major reason not to delay is that poor sleep can reflect something undiagnosed

Evidence for the last three metabolites has only been obtained in vitro

Although studies are mixed, vitamin D may make severe flu and COVID-19 infections less likely

However, post-mortem tissue provides only a static snapshot in time