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Studies have also indicated interactions with opioid pathways DSIP administration has been shown to modulate pain perception and has effects that can be partially blocked by opioid antagonists in some paradigms, suggesting opioidergic involvement in at least some of its actions

Cell proliferation Proliferation of U87vIII CHCHD2 WT and KO cells was compared over 72 h in normoxic culture conditions (20% O2) and hypoxia (1% O2) using the sulforhodamine B assay according to published protocols [29]

We noted an intriguing observation that K l-la on core histones, rather than linker histones, displayed a markedly more pronounced response to high glucose conditions

This, in turn, led to a substantial reduction in energy metabolism in Huh7 and Hep3B cells