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however, further analysis is necessary to confirm a role for the Ku antigen complex and ORE sequences in modulating hypoxic responses in vivo and in cells other than cardiomyocytes and to define the mechanism by which they respond to oxygen tension

The mitochondrial pyruvate carrier (MPC) regulates the entry of glycolytic pyruvate into the mitochondria, serving as a key node linking glycolysis to OXPHOS [51]