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In addition, heme degradation mediated by heme oxygenase-1 (HO-1) releases iron and is therefore associated with ferroptosis

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Green tea polyphenol EGCG has been shown to activate the antioxidant defense system in chondrocytes by inhibiting ERK and p12 MAPK activation while blocking pro-inflammatory signaling pathways, thereby alleviating RA (127)

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