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These challenges span mechanistic understanding, therapeutic design, and clinical validation

It suggests that the brain is more responsive to therapy when supported by peptides

A multicentre retrospective study of 499 patients identified ICI patients with renal cell carcinoma (RCC) in which 80 patients developed severe irAEs warranting treatment cessation, 36 of whom were able to be restarted on an ICI agent and 44 permanently discontinued

-HB has been shown to exert neuroprotective effects on dopaminergic neurons [52], with consistent evidence from MPTP-induced models of PD, where it prevents the loss of dopaminergic cells in the substantia nigra [53]