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They provide strong proof that a compound has a direct biological effect on the target tissue, but they cannot tell us how that compound will behave when applied to human skin (where absorption, distribution, and metabolism add complexity)

An interesting experiment shows how, in the presence of insulin resistance, there is up-regulation of the insulin/IGF-1 hybrid receptor expression in both, muscle and fat [133, 156]

Moreover, medications for gastritis, such as proton pump inhibitors, have been reported to inhibit gastric acid production, which might also cause malabsorption of vitamin B 12 [18, 20]

While, in westernized societies, acne is a nearly universal skin disease afflicting up to 95 percent of teens, in some populations eating more traditional diets, not even single cases could be found