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The geometric LS mean ratios of the AUC inf were 1.53, 2.30, and 3.69 in the mild renal impairment, moderate renal impairment, and severe renal impairment groups, respectively, versus matched normal renal function groups

ISSN 18716032;PAGE 15:Abstr 937 [ Mallet A, Mentre F, Steimer JL, Lokiec F (1988) Nonparametric maximum likelihood estimation for population pharmacokinetics, with application to cyclosporine

this is a maximum hypersensitivity reaction of the immune system with varying degrees of severity, but which can be acutely life-threatening (Bilwani et al., 2005)

B12 shot schedule: loading and maintenance Protocols vary by country and scenario