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Oxidative and antioxidative potential of brain microglial cells

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In the experience of the authors of the present publication, local botulinum toxin application might be considered in single individuals with pain refractory to maximized oral or transdermal treatment, especially in case of on- and off dystonia, muscular pain trigger points, painful myotonus, spasms in the esophagus, pylorus, anal sphincter or hyperactive bladder [29]

Those with diseases like Crohn's disease and celiac disease are also at risk, because these conditions hinder the body's ability to absorb B12