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The OMM fusion is critically mediated by the large membrane GTPases mitofusin 1 (MFN1) and MFN2 [Figure 2]

The pentapeptide PHTrP107-111 (osteostatin), which includes the Thr-Arg-Ser-Ala-Trp sequence from the C-terminal fragment of PTH-related proteins, promotes osteogenic differentiation of MSCs, inhibits senescence and inflammation in osteoarthritic osteoblasts, reverses skeletal alterations associated with IGF-1 deficiency, and improves bone regeneration in animal models of bone defects [95, 96]

What If the Numbers Are Too High or Not Right

It is better to take a smaller, highly absorbable dose every day than a massive dose once a week