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Human and animal studies have shown that crocin offers many health benefits, includinganti-inflammatory, antioxidant, andanti-anxiety and antidepressanteffects

In: Histamine: Biology and Medical Aspects

Another study investigated the developmental changes in tonic and phasic inhibition using the visual cortex as a model in Cntnap2 KO mice, revealing that Cntnap2 deficiency causes developmental disruption of GABA neurotransmission, particularly a reduction in tonic inhibition

As the authors point out, these findings may help to explain why these metabolic abnormalities occur in a cluster (such as found in the metabolic syndrome), partly because people are exposed to low doses of various POPs simultaneously