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Description

In placental development, HO-1 is highly expressed and fulfills essential physiological roles: it is enriched in trophoblast cells, where it modulates EVTs invasion via upregulation of peroxisome proliferator-activated receptor (PPAR) [30, 70], a key regulator of trophoblast differentiation and spiral artery remodeling

These findings suggest a promising avenue for combination treatment, which now needs evaluation in patients

Puluhulawa LE, Joni IM, Elamin KM, Mohammed AFA, Muchtaridi M, Wathoni N (2022) Chitosan-hyaluronic acid nanoparticles for active targeting in cancer therapy