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However, both can cause water retention, carpal tunnel symptoms, and effects on glucose metabolism at higher doses

This research highlights the potential of pharmacological modulation of ferroptosis, either by inhibition or stimulation, as a therapeutic approach for illnesses associated with dysregulated lipid peroxidation (22)

Hepatotoxicity of a Cannabidiol-Rich Cannabis extract in the mouse model

Interestingly, the selective deletion of SLC25A37 in hepatocytes has no phenotype under normal conditions, but it can cause protoporphyria and hepatotoxicity in delta aminolevulinic acid (a precursor of porphyrin biosynthesis)-fed animals (Troadec et al., 2011)