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In fact, studies suggest it takes significantly more force to produce symptoms in children, meaning that when symptoms do appear, the impact may have been more substantial (2)

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Thus, XLSAA has characteristics of both an X-linked disorder and a mitochondrial cytopathy

Upregulation of IL-17 activates parenchymal cells and subsequently induces an influx of polymorphonuclear cells to the infection site mediated by CXCL1, CXCL3, and CXCL5 (106)