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When semaglutide molecules begin to unfold slightly, their hydrophobic regions become exposed to the aqueous environment

doi:10.1016/j.ajpath.2012.08.004 Dragovic S, Boerma JS, van Bergen L, Vermeulen NP, Commandeur JN (2010) Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine