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Sies H, Belousov VV, Chandel NS, Davies MJ, Jones DP, Mann GE, et al

High-fat diet and antibiotics cooperatively impair mitochondrial bioenergetics to trigger dysbiosis that exacerbates pre-inflammatory bowel disease

Several metabolic approaches improving mitochondrial function have been investigated in vitro and in vivo and showed varying effects in ALS

Now known as the FoyerHalliwellAsada pathway, this sequence of reactions notably links reduction of H 2 O 2 , catalysed by ascorbate peroxidase, to oxidation of NADH or NADPH, catalysed by monodehydroascorbate reductase and glutathione reductase