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The key epigenetic regulatory mechanisms including DNA methylation, post-translational histone modifications, and the functions of non-coding RNAs, are critically involved in the initiation, maintenance, and progression of microvascular and macrovascular complications in DM [106, 107]

Historically, tumor-associated macrophages were defined as immune cells capable of phagocytosing cancer cells, resulting in lethal consequences, and were initially categorized as anti-tumorigenic entities (27)

Therefore, liquid biopsy based on blood samples has emerged as a valuable tool for the early detection of BC

Endovascular perforation murine model of subarachnoid hemorrhage