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Vitamin B12 is a water-soluble vitamin, meaning the body does not store excess amounts in fat tissues

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For example, after a 12-week cycle, a 4- to 6-week break is often sufficient for biomarkers to normalize

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Conservative stacking protocols start with lower tirzepatide doses (510mg weekly) and moderate 5-amino-1MQ doses (50mg daily) to minimize additive metabolic stress while monitoring tolerability

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Funding This work was supported by the Natural Science Foundation Council of China (81922081and 81700780)

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