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Human MTs can be classified into four classes, namely MT1 to MT4, comprising a total of eleven functional isoforms, with eight of them belonging to class 1

The conversion of vitamin B 6 to its active coenzyme form in tissues, pyridoxal 5'-phosphate (PLP), requires the FMN-dependent enzyme, pyridoxine 5'-phosphate oxidase (PPO) (7)

J Membr Biol 69:112 Mulcahy RT, Bailey HH, Gipp JJ (1995) Transfection of complementary DNAs for the heavy and light subunits of human gamma-glutamylcysteine synthetase results in an elevation of intracellular glutathione and resistance to melphalan

Cell death in the liver may be exacerbated by a deficiency in antioxidants, including glutathione