mechanism production of glutathione SYNTHESIS mechanism production of glutathione SYNTHESIS

Rivera, H

Since GSTO1 overexpression has been implicated in drug resistance, particularly to platinum compounds 7,18,19 , we tested the effects of GSTO1 inhibitors in combination with cisplatin in HCT116 cells

Several studies have shown that factors such as mitophagy, oxidative stress, differentiation, and quality control, differentially influence mitochondrial function to promote liver fat accumulation and injury

For example, one study published in 2014 showed that NSCLC patients with higher numbers of CTCs at baseline, as determined using the CellSearch methodology, demonstrated worse overall and progression-free survival than patients with lower CTC counts