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Similar to other antioxidants, NAC may exhibit pro-oxidant actions, but these are generally limited to higher doses of 5501500 mg/kg/day [117,118,119]

Ongoing pharmacologic strategies aim to maintain or improve muscle mass during GLP-1RA therapy

Abbreviations NAPDH : Nicotinamide adenine dinucleotide phosphate NOX2 : Gp91phox subunit of the NADPH oxidase Rac1 : Ras-related C3 botulinum toxin substrate 1 ROS : Reactive oxygen species References Ago T, Kitazono T, Ooboshi H, Iyama T, Han YH, Takada J, Wakisaka M, Ibayashi S, Utsumi H, Iida M (2004) Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase

For patients with mild or moderate AWS, an outpatient setting compared to inpatient can be relatively safe and effective, have lower costs, and be acceptable due to the reduced impact on the patients personal life