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Mock-treated fibroblasts were used as controls

Systemic immunization (SC x4) with a vaccine composition comprising 4 pharmamers compricing 1 -3 of the 5 biologically active molecules denoted above and comprising the adjuvant Titermax Gold in group 2 macaques elicited a significant decrease in both the peak viral load 2-3 weeks after IV challenge with SHIV SF162.P4 and the cumulative viral load over the whole period of 10 weeks (p 1 , wherein a and b together form a functional MHC protein capable of binding the peptide P, when P is present wherein (a-b-P) is the MHC-peptide complex formed when the peptide P binds to the functional MHC protein, wherein each MHC peptide complex is associated with one or more multimerization domains