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Intentional opening of the BBB presents considerable challenges, as it compromises a critical protective barrier of the central nervous system

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An exemplary batch of gel formulation as described in Example Al is prepared containing, for example, 1.5% of transplatin is prepared by dissolving Poloxamer 407 (BASF Corp.) in 50 mM Tris buffer and 77 mM NaCl solution with a pH between 5.5-8.0

It also concerns economic actors " who have effects in Switzerland, even if they were produced abroad ." These actors may be foreign companies: Commercially active on the Swiss market