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A translational review on NNMT inhibitor clinical development ( Emerging opportunities for NNMT inhibitor clinical translation , ScienceDirect, 2026) points out that alternative routes like polyamine biosynthesis could compensate for the raised SAM, and that partial rather than total inhibition might even be preferable specifically to avoid triggering those compensatory mechanisms from a chronically imbalanced SAM/SAH ratio

The specific usage regimen of AOD9604 is not detailed in the provided articles

Reported or plausible effects may include headache, nausea, dizziness, flushing, fatigue, or changes in sleep

Notably, AOD9604 also appears to interact with HSL and ACC, but does not support carbohydrate metabolism or insulin sensitivity