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Tumors with high OXPHOS dependency may be particularly susceptible to mitochondrial inhibitors, but patient selection based on metabolic profiling is critical for therapeutic success [34]

PMC 4693248

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In addition, tumor-associated intrinsic pathways such as MAPK/PI3K , WNT/-catenin , and PD-1 are closely associated with tumor angiogenesis, and interactions among these pathways affect DC maturation, and T-cell recruitment and activation, and subsequently promote drug resistance in breast cancer