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These results led to the development of the ortho -carborane building block 9-(carboxymethylthio)-1,2-dicarba- closo -dodecaborane(12) and a deoxygalactosyl-functionalized, charge-compensated cobalt bis(dicarbollide) building block, which were introduced at position 4, 18, or 22 of [F 7 ,P 34 ]NPY by the side-chain of substituted lysines at the respective positions (Ahrens et al., 2016)

By using this side door into brain cells, leucovorin can restore folate levels in the brain and support normal neuronal functioning despite the antibody interference [3]

Interestingly the Pro37 adjacent to the catalytic Cys is also found in the vast majority of sequences

During that time, artillery support was ineffective, as Civil Guard forward observers would not stand up to observe the fall of artillery rounds