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The NAD+-Dependent deacetylase SIRT1 modulates CLOCK-Mediated chromatin remodeling and circadian control

Importantly, VC synergizes with conventional therapies by radio-sensitizing hypoxic tumors through oxygen-sparing effects and reversing platinum resistance via glutathione depletion

Unlike depressive episodes in MDD, which tend to be associated with a reduction of GDNF, bipolar depression does not seem to influence GDNF levels (237)