As described earlier in this final rule, after consideration of comments received, we revised 428.202(d) to add a paragraph (3), which provides that to the extent that a new NDC-9 of a Part D rebatable drug is reported under section 1927 of the Act and AMP has not been reported for such NDC-9 under section 1927(b)(3)(A)(i)(I) or (ii) of the Act during the period described 428.202(c)(1) or (2), as applicable, CMS will identify the payment amount benchmark period and calculate the benchmark period manufacturer price for such NDC-9 using other information reported by a manufacturer under section 1927(b)(3) of the Act for the Part D rebatable drug, as available, such as the base date AMP if such base date AMP is reported for a calendar quarter that overlaps with the period described at 428.202(c)(1) or (2), as applicable
The 2.4 mg maintenance dose is close to the 1 mL capacity of a standard U-100 insulin syringe, which is why some community sources reconstitute cagrilintide at higher concentration (e.g., 5 mg in 1.5 mL 3.33 mg/mL 2.4 mg = 0.72 mL = 72 units) to keep dose volume manageable
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On a cellular level, MOTS-c reprograms fuel utilization in ways that favor metabolic health
