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Structure superimposition demonstrated that the epitope for WRAIR-5001 is occluded by the adjacent S protomers when the RBD is in the down conformation while more accessible when RBD is in the open conformation, indicating the cryptic nature of this epitope in line with other mAbs in class III or class V

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72 TNF- stimulates the pulmonary microvascular endothelial cells to promote the accumulation, adhesion and migration of the polymorphonuclear leucocytes by inducing the expression of IL-8 and upregulating endothelial adhesion molecules, causes release of lysosomal enzymes, elastase and large quantities of ROS