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Co-expression of ACE2 with membrane serine proteases is high on ileal absorptive enterocytes in the GI tract, nasal goblet secretory cells and type II pneumocytes in the respiratory tract, as well as on the urogenital epithelia 59,60

Rapid lipolysis increases oxidative stress markers

Figure 5 Functional enrichment analysis of DEG identified in the contrasts above mentioned revealed 90 metabolic and signaling pathways differentially regulated in the groups MOD or SEV at endpoint A directly or indirectly related to the inflammatory response in blood, although patients had received glucocorticoid treatment for approximately 11 days prior to collection of samples to the study ( Figure 6A and Figure S4 )