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Tricarboxylic acid cycle metabolites as mediators of DNA methylation reprogramming in bovine preimplantation embryos

Accumulating evidence shows a critical link between inflammation and the chronic promotion/progression of various human diseases, including atherosclerosis, diabetes, arthritis, inflammatory bowel disease, cancer, and Alzheimers disease (Wei et al., 2013)

These modifications are also believed to assist at least 90% of the peptide to bind covalently to blood albumin, with trace amounts potentially binding to fibrinogen and immunoglobulin G (IgG)

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