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FIGURE 4 3.4 Nitazoxanide reduced apoptosis in rats with MTX-hepatotoxicity MTX significantly induced hepatic apoptosis as demonstrated by increased proapoptotic markers, Bax level, and caspase-3 activity (Figures 5A, D) while reduced antiapoptotic Bcl-2 level (Figure 5B) and increased Bax/Bcl-2 ratio (Figure 5C) compared to CTRL group

Indeed, they can contribute to the development of liver disease, Alzheimers, Parkinsons, cancer, diabetes, stroke, and heart attack

Minocycline and hydroxy-chloroquine exhibit immuno-modulatory and anti-inflammatory properties however their use has not been well established [ 8 ]