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While they can offer antioxidant support and brighten surface-level pigmentation, their effects are limited compared to oral or injectable forms, as glutathione molecules struggle to penetrate deeply into skin layers

miRNA regulation of glutathione homeostasis in cancer initiation, progression and therapy resistance

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The GPR30 receptor agonist G1 inhibits ferroptosis and significantly improves chondrocyte viability and motor ability in mice through the YAP1/FTH1 pathway, while GPR30 receptor antagonist G15 has the opposite effect, suggesting that hormone-related ferroptosis may emerge as a promising target for alleviating osteoarthritis in postmenopausal women