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You must use trial and error, starting with a standard initial dose and gradually increasing the amount until you obtain the best results

In vitro studies using MDCK cells (a model of intestinal epithelial permeability) demonstrated that PLGA nanoparticles significantly enhanced cellular uptake and transport of puerarin across cell monolayers, achieving a permeability coefficient value of 2.83 0.27 10 5 cm/s, which was significantly higher than that observed for free puerarin (0.38 0.07 10 5 cm/s)

5 In this article, we will combine the most up-to-date and clinically relevant efficacy data, the most recent cost data and the latest epidemiology data from a large Italian ICU database to determine whether i.v