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149 , 671684.e679 (2022)

Additionally, downregulation of nuclear factor erythroid 2-related factor 2 (Nrf2), a crucial regulator of the cellular antioxidant response, compromises the hepatocytes first-line defence against oxidative injury [50, 51]

This action initiates a cascade of nutritional benefits

In contrast, several differentially expressed genes (e.g., CDH2 ) and associated pathways and processes suggested that GSTP1 knockdown may significantly inhibit cell invasion and migrationthese predictions were confirmed experimentally, and are consistent with the hypothesis that increased GSTP1 expression promotes neoplastic transformation and the development of drug resistance