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Across preclinical work, the most consistent signals are Remodeling of the extracellular matrix, including collagen and elastin pathways Anti inflammatory actions and modulation of oxidative stress markers Support for repair processes in tissue and skin models Human clinical data exist, but they are limited in size and quality

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Initial short-term outcomes of CA for AWE published in 2014 have shown promising safety and efficacy profiles, confirmed by subsequent mid- and long-term studies that indicate significant and sustained pain reduction [8, 12]