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Such maladaptive neural plasticity could lead to abnormal patterns of autonomic and neuroendocrine acitivity.35,36 The fact that vomiting and retching during the emetic phase of CVS are mainly produced when the stomach is empty, implies that the allostatic feedback mechanisms are disordered, which could give rise to a reduced threshold for vomiting and retching, regardless of physiologic necessity or peripheral information

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Humans become infected most frequently through contaminated water or food

Indeed, IDH1 inhibition or glutamine starvation in MYC-overexpressing cells decreased KG abundance (Extended Data Fig