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Thus these findings demonstrate the important role of GSH to maintain intestinal morphology and function, and that, at least, in the TNBS+ethanol-induced colitis, mucosal damage is caused by both depletion of GSH and ROS generation

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RIG-I (DDX58) interacts with MDA-5 and utilizes the mitochondrial adapter protein Cardif (IPS-1) to upregulate the expression of BH3-only proteins Puma and Noxa, thereby promoting intrinsic apoptosis in melanoma cells [162]

In this context, actin in phagosomes and ruffled membranes is differentially regulated by the function of Ly49Q