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28-31 These findings imply that there might be a common central pathogenesis and pathophysiology for these disorders

6 With regard to metabolism , individuals inherit different metabolic predispositions

(3) Condensation of the tail and head group: Once both the benzoquinone head group precursor (4-HB) and the isoprenoid side chain (polyprenyl pyrophosphate, PPP) are synthesized, the enzyme COQ2 catalyzes their condensation via an electrophilic aromatic substitution 33