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It has also been reported that GA treatment attenuated the expression TGF-1/Smad signaling induced pressure overload ( Cardiac collagen tissue remodeling is an important event in the progression of heart failure

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Ri and R 2 are independently selected from the group consisting of H, linear or branched alkyl (1-25C), aralkyl (6-26C), cycloalkyl (6-25C), heterocycles (6-20C), ethers or polyethers (3-25C), and where Ri-R 2 together have 2-20C atoms and form a macrocycle with the remainder of formula I

Hermizi H, Faizah O, Ima-Nirwana S, Ahmad Nazrun S, Norazlina M: Beneficial effects of tocotrienol and tocopherol on bone histomorphometric parameters in SpragueDawley male rats after nicotine cessation