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Funding This study was supported by grants from the National Natural Science Foundation of China (82570731, 82170627), Basic-clinical integration innovation project of the Xian Jiaotong University (YXJLRH2022042, YXJLRH2022048), Key Research and Development Program of Shaanxi (2023-YBSF-350, 2024SF-YBXM-117) and Outstanding Youth Fund of Xian Jiaotong University (2022YQPY04), Institutional Foundation of The First Affiliated Hospital of Xian Jiaotong University (2021ZYTS-36, 2022MS-27)