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Under the influence of the angiogenic factors released by the cancer cells, like VEGF and PDEGF, the endothelial cells express higher levels of the relevant receptors

Besides, when the human body inhales PM2.5, the molecular mechanisms of ferroptosis in endothelial cells as the first line of defense include GSH depletion combined with iron metabolism disorder (Wang and Tang, 2019)

Cell viability was assessed using the CCK-8 assay (Dojindo, Japan), and optical density (OD) was measured at 450 nm using a VARIOSKAN LUX reader (Thermo Fisher Scientific, USA)

Initially following exposure to a xenobiotic inducer, periportal hyperplasia occurs as an early response, evident before there is obvious centrilobular hepatocellular hypertrophy