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In some embodiments, the amount of thermoreversible polymer (e.g., pluronic F127) in any formulation described herein is about 12% of the total weight of the formulation

In general, it is reasonable to allow enough time to assess changes in symptoms, sleep, mood, cognition, and any side effects before introducing an additional compound

Thus MET overexpression can promote an increase in drug efflux through regulating the expression of efflux transporters, leading to chemoresistance and increased cell survival

In some formulations developed for administration to a mammal, and for formulations formulated for human administration, the auris-acceptable gel comprises substantially all of the weight of the formulation