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The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia

Furthermore, studies using DSSinduced colitis models demonstrated significantly increased syn expression in the colon and notable syn deposits in the brain [132], supporting the hypothesis that the gastrointestinal tract serves as an initial site for syn pathology, which may then propagate to the CNS via the vagus nerve [23]

Schweizer, U., Weitzel, J

In addition, the inflammation impacts the kidneys and causes a reduced blood flow through the urinary system, which increases blood pressure in the body