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DIO1 and DIO2 are in charge of the activation of the thyroid hormones T4, T3 and rT3

The mitochondrial oxidoreductase CHCHD4 is present in a semi-oxidized state in vivo

In a chronic stress scenario, indeed, norepinephrine and cortisol overproduction can activate microglia and mast cell trough NLRP3 inflammasome, with release of pro-inflammatory cytokines, such as IL-1 and TNF-, and Reactive Oxygen Species (ROS) [55], causing neuroinflammation and depression [56]