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A CIC target binding octamer sequence occurs in the promoter regions of the folate transport genes FR, PCFT, and RFC1, and dihydrofolate reductase, and binding was confirmed by chromatin immunoprecipitation assays

However, there are some intriguing varia- tions in organisms such as halobacteria, in which GSH can be replaced by other sulphur compounds like g- glutamylcysteine (g-EC) and thiosulphate (Newton & Javor 1985)