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Although all of the available studies have methodological limitations, the weight of the evidence supports the conclusion that valproate exposure in utero can cause decreased IQ in children

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Biometrics 56, 455463 (2000)

In addition, polyamines regulate the Wnt/-catenin signaling pathway through spermidine/spermidine-N (1) -acetyltransferase (SSAT) activity, further promoting tumor proliferation (Wang et al., 2017)