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In anterograde regulation, proteins encoded by the nuclear genome are transferred to the mitochondria to perform functions ( 2+ release ( Mitochondrial biogenesis is mainly controlled by a network of transcription factors in the nucleus, including peroxisome proliferator-activated receptor (PPAR), peroxisome proliferator-activated receptor (PPAR), estrogen-related receptors (ERRs), cylic AMP (cAMP) response element-binding protein (CREB), forkhead box (FOXO), and peroxisome proliferator-activated receptor coactivator-1 (PGC-1) ( Testosterone promotes biogenesis by activating the AR/PGC-1/TFAM pathway in the skeletal muscle ( Pgc-1 and Tfam genes in C 2 C 12 myogenic cells ( Pgc-1 and Nrf-1 are directly regulated by AR
In exceptional cases, if there are current and urgent indications of abuse, it can also be amended before the end of a year
Yuan et al., 2016), but also enhance the sensitivity of cancer cells to chemotherapy drugs or metabolic signaling inhibitors (Xie et al., 2016
