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Description

Metabolic efficiency signalling: Increased cellular energy expenditure readouts observed in structured preclinical systems

doi: 10.1006/cryo.1993.1036 27

Natural IgM has low affinity and high avidity (polyreactivity) and plays a paramount role in primary host defense, since it contains more flexible constitutive antigen-binding sites that enhance interactions with numerous antigens, including viruses and bacteria (224, 225)